منابع مشابه
Large-scale digitoxin intoxication.
Because of an error in the manufacture of digoxin tablets a large number of patients took tablets that contained 0.20 mg. of digitoxin and 0.05 mg. of digoxin instead of the prescribed 0.25 mg. of digoxin. The symptoms are described of 179 patients who took these tablets and suffered from digitalis intoxication. Of these patients, 125 had taken the faultily composed tablets for more than three ...
متن کاملI. Protection against Lethal Digitoxin Intoxication
This work was presented in part at the 62nd Annual Meeting of the American Society for Clinical Investigation, May 1970, Atlantic City, N. J. Received for publication 16 September 1970 and in revised form 12 August 1971. The data obtained in this study indicate that cholestyramine treatment affords a significant degree of protection against lethal digitoxin intoxication in rats and guinea pigs....
متن کاملInterruption of the enterohepatic circulation of digitoxin by cholestyramine. I. Protection against lethal digitoxin intoxication.
Previous studies have demonstrated that considerable amounts of parenterally administered cardiac glycosides are excreted in the bile and reabsorbed across the intestinal mucosa in several species. It is currently believed that the more prolonged action of nonpolar digitalis glycosides is due to their retention and recycling in the enterohepatic circulation. This report describes studies carrie...
متن کاملAccidental digitoxin intoxication: an interplay between laboratory and clinical medicine
INTRODUCTION Two Italian adults arrived at the Emergency Department referring diarrhea, nausea and vomiting for 4 days; weakness, fatigue and visual hallucinations were also complained of. Patients reported the ingestion of some leaves of a plant, which they supposed to be "donkey ears", a week before. Physical examination showed hypotension and bradycardia and ECG examination disclosed sinus r...
متن کاملDigitoxin—A Critical Review *
Within recent years, there has been an increasing interest in purified digitalis preparations. However, in spite of the original optimistic reports , the recent literature tends to discredit the value of the new preparations. Most criticisms fall into two groups: (A) Inadequacy of digitali-zation with the original recommended dosage schedules. (B) Increase in the incidence of drug toxicity. It ...
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ژورنال
عنوان ژورنال: BMJ
سال: 1970
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.3.5725.737